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慢性阻塞性肺疾病（COPD）是一种常见的慢性呼吸系统疾病。该病的发生不仅会对患者的呼吸系统功能造成影响，还与认知功能障碍（CI）存在密切联系。文章结合近年来的相关研究，对COPD合并CI的发病机制、诊断方法以及干预措施进行综述，旨在为进一步深入研究和临床实践提供参考。
Abstract：Chronic Obstructive Pulmonary Disease(COPD) is a common chronic respiratory disease, which not only affects the respiratory system function of patients, but also has a close association with cognitive impairment(CI). Based on the relevant studies in recent years, this article reviews the pathogenesis, diagnostic methods and intervention measures of COPD complicated with CI, aiming to provide references for further in-depth research and clinical practice.
[1]MUNISH SHARMA,SUSHIL JOSHI,PRAKASH BANJADE,et al.Global Initiative for Chronic Obstructive Lung Disease(GOLD)2023 Guidelines Reviewed[J].Open Respir Med J,2024,10(18):e18743064279064.
[2]WANG T,MAO L,WANG J,et al.Influencing factors and exercise intervention of cognitive impairment in elderly patients with chronic obstructive pulmonary disease[J/OL].Clinical Interventions in Aging,2020,15:557-566.
[3]SIRAJ RA.Comorbid cognitive impairment in chronic obstructive pulmonary disease(COPD):current understanding,risk factors,implications for clinical practice,and suggested interventions[J/OL].Medicina(Kaunas,Lithuania),2023,59(4):732.
[4]VON SIEMENS SM,PERNECZKY R,VOGELMEIER CF,et al.The association of cognitive functioning as measured by the Dem Tect with functional and clinical characteristics of COPD:results from the COSYCONET cohort[J].Respir Res,2019,14,20(1):257.
[5]DOBRIC A,DE LUCA SN,SPENCER SJ,et al.Novel pharmacological strategies to treat cognitive dysfunction in chronic obstructive pulmonary disease[J].Pharmacol Ther,2022,233:108017.
[6]TORRES-SÁNCHEZ I,RODRÍGUEZ-ALZUETA E,CABRERA-MARTOS I,et al.Cognitive impairment in COPD:a systematic review[J/OL].Jornal Brasileiro De Pneumologia:Publicacao Oficial Da Sociedade Brasileira De Pneumologia E Tisilogia,2015,41(2):182-190.
[7]CLEUTJENS FAHM,JANSSEN DJA,PONDS RWHM,et al.COgnitive-pulmonary disease[J/OL].Bio Med Research International,2014,2014:1-8.
[8]TORRES-ACOSTA N,O'KEEFE JH,O'KEEFE EL,et al.Therapeutic potential of TNF-α inhibition for alzheimer's disease prevention[J/OL].Journal of Alzheimer's disease:JAD,2020,78(2):619-626.
[9]宋飞云,丁可欣,孙雯,等.COPD家庭肺康复方案改善认知功能的研究进展[J/OL].湖北民族大学学报(医学版),在2024,41(1):94-98.
[10]FENG L,WANG Y,ZENG D,et al.Predictors of cognitive decline in older individuals without dementia:An updated meta-analysis[J].Ann Clin Transl Neurol,2023,10(4):497-506.
[11]PELGRIM CE,PETERSON JD,GOSKER HR,et al.Psychological co-morbidities in COPD:targeting systemic inflammation,a benefit for both?[J/OL].European Journal of Pharmacology,2019,842:99-110.
[12]BARNES PJ.Inflammatory mechanisms in patients with chronic obstructive pulmonary disease[J/OL].The Journal of Allergy and Clinical Immunology,2016,138(1):16-27.
[13]HUANG HH,CHANG JC,LIU HC,et al.Handgrip strength,tumor necrosis factor-α,interlukin-6,and visfatin levels in oldest elderly patients with cognitive impairment[J].Exp Gerontol,2020,142:111138.
[14]XU J,ZENG Q,LI S,et al.Inflammation mechanism and research progress of COPD[J/OL].Frontiers in Immunology,2024,15:1404615.
[15]CAO P,ZHANG C,HUA DX,et al.Serum 8-hydroxy-2'-deoxyguanosine predicts severity and prognosis of patients with acute exacerbation of chronic obstructive pulmonary disease[J/OL].Lung,2022,200(1):31-39.
[16]CIOFFI F,ADAM RHI,BANSAL R,et al.A review of oxidative stress products and related genes in early alzheimer's disease[J/OL].Journal of Alzheimer's disease:JAD,2021,83(3):977-1001.
[17]WEN T,ZHANG Z.Cellular mechanisms of fibrin(ogen):insight from neurodegenerative diseases[J/OL].Frontiers in Neuroscience,2023,17:1197094.
[18]BUTTERFIELD DA.Brain lipid peroxidation and alzheimer disease:synergy between the butterfield and mattson laboratories[J/OL].Ageing Research Reviews,2020,64:101049.
[19]LIU S,GAO X,ZHOU S.New Target for Prevention and Treatment of Neuroinflammation:Microglia Iron Accumulation and Ferroptosis[J].ASN Neuro,2022,14:17590914221133236.
[20]MIJAILOVIC NR,VESIC K,BOROVCANIN MM.The influence of serum uric acid on the brain and cognitive dysfunction[J/OL].Frontiers in Psychiatry,2022,13:828476.
[21]HUANG S,WANG J,FAN DY,et al.The association of serum uric acid with cognitive impairment and ATN biomarkers[J/OL].Frontiers in Aging Neuroscience,2022,14:943380.
[22]KIM JW,BYUN MS,YI D,et al.Serum uric acid,alzheimer-related brain changes,and cognitive impairment[J/OL].Frontiers in Aging Neuroscience,2020,12:160.
[23]DAG E,BULCUN E,TURKEL Y,et al.Factors influencing cognitive function in subjects with COPD[J/OL].Respiratory Care,2016,61(8):1044-1050.
[24]KAKKERA K,PADALA KP,KODALI M,et al.Association of chronic obstructive pulmonary disease with mild cognitive impairment and dementia[J/OL].Current Opinion in Pulmonary Medicine,2018,24(2):173-178.
[25]OUELLETTE DR,LAVOIE KL.Recognition,diagnosis,and treatment of cognitive and psychiatric disorders in patients with COPD[J/OL].International Journal of Chronic Obstructive Pulmonary Disease,2017,12:639-650.
[26]陈秋艳,蒋育悦,胡如海,等.慢性阻塞性肺疾病患者认知功能障碍的研究进展[J/OL].实用临床医药杂志,2021,25(1):117-120.
基本信息:
DOI：10.16068/j.1000-1824.2026.02.005
中图分类号:R563.9;R749.1
引用信息:
[1]林炯亮,夏诗林,穆清爽.慢性阻塞性肺疾病与认知功能障碍的研究进展[J].延边大学医学学报,2026,49(02):16-19.DOI:10.16068/j.1000-1824.2026.02.005.
基金信息:
“天山英才”医药卫生高层次人才培养计划（编号：TSYC202301B062）
2025-10-17
2025
2025-10-28
2025
1
2026-02-28
2026-02-28