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糖尿病足溃疡（DFUs）是导致截肢的重要病因，临床需探究DFUs愈合障碍的机制，以寻找治疗靶点。细胞周期蛋白D1(Cyclin D1)是调控细胞G1/S期转换的关键因子，对创伤修复至关重要。在糖尿病环境中，Cyclin D1低表达不利于创面修复。现综述Cyclin D1在糖尿病创面愈合中的作用机制及进展。
Abstract：Diabetic foot ulcers(DFUs) are a major cause of amputations, necessitating clinical exploration into the mechanisms underlying impaired DFU healing to identify therapeutic targets. Cyclin D1 is a key regulator of the G1/S phase transition in the cell cycle and is crucial for wound repair. In a diabetic environment, the low expression of Cyclin D1 is detrimental to wound healing. This article reviews the mechanism and progress of Cyclin D1 in diabetic wound healing.
[1]YOUNES N A,ALBSOUL A M,AWAD H.Diabetic heel ulcers:a major risk factor for lower extremity amputation[J].Ostomy Wound Manage,2004,50(6):50-60.
[2]WANG P H,HUANG B S,HORNG H C,et al.Wound healing[J].J Chin Med Assoc,2018,81(2):94-101.
[3]LI X,WU G,HAN F,et al.SIRT1 activation promotes angiogenesis in diabetic wounds by protecting endothelial cells against oxidative stress[J].Arch Biochem Biophys,2019,661:117-124.
[4]BERLANGA-ACOSTA J A,GUILLEN-NIETO GE,RODRÍGUEZ-RODRIGUEZ N,et al.Cellular senescence as the pathogenic hub of diabetes-related wound chronicity[J].Front Endocrinol(Lausanne),2020,11:573032.
[5]HUANG J,DENG Q,TSANG L L,et al.Mesenchymal stem cells from perinatal tissues promote diabetic wound healing through PI3K/AKT pathway activation[J].Stem Cell Res Ther,2023,14(1):19.
[6]ALMEIDA M E,MONTEIRO K S,KATO E E,et al.Hyperglycemia reduces integrin subunits alpha v and alpha 5 on the surface of dermal fibroblasts contributing to deficient migration[J].Mol Cell Biochem,2016,421(1-2):19-28.
[7]谢挺,陆树良.糖尿病大鼠皮肤组织表皮细胞增殖相关事件的研究[J].上海第二医科大学学报,2005,25(6):541-544.
[8]HSIEH M W,WANG W T,LIN C Y,et al.Stem cell-based therapeutic strategies in diabetic wound healing[J].Biomedicines,2022,10(9):2085.
[9]ZHONG Q L,LIU F R,LIU D W,et al.Expression of β-catenin and cyclin D1 in epidermal stem cells of diabetic rats[J].Mol Med Rep,2011,4(2):377-381.
[10]LI J Z,ZHOU X X,WU W Y,et al.Concanavalin A promotes angiogenesis and proliferation in endothelial cells through the Akt/ERK/Cyclin D1 axis[J].Pharm Biol,2022,60(1):65-74.
[11]MONTALTO F I,DE AMICIS F.Cyclin D1 in cancer:A molecular connection for cell cycle control, adhesion and invasion in tumor and stroma[J].Cells,2020,9(12):2648.
[12]DAN J,TAN T,WU M,et al.Lithium chloride promotes diabetic corneal epithelial wound healing by activating the Wnt/β-catenin signaling pathway[J].Exp Ther Med,2023,26(2):373.
[13]DALGAARD L T.Mechanistic actions of micro RNAs in diabetic wound healing[J].Cells,2020,9(10):2228.
[14]HUANG Q,CHU Z,WANG Z,et al.circ CDK13-loaded small extracellular vesicles accelerate healing in preclinical diabetic wound models[J].Nat Commun,2024,15(1):3904.
基本信息:
DOI：10.16068/j.1000-1824.2026.02.001
中图分类号:R587.2
引用信息:
[1]苏比努尔·乌拉木,贾梦琦,梁修毓,等.Cyclin D1在糖尿病足慢性创面愈合中的作用机制与研究进展[J].延边大学医学学报,2026,49(02):1-3.DOI:10.16068/j.1000-1824.2026.02.001.
2026-02-28
2026-02-28