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人参（Panax ginseng）作为一种传统中药，因其丰富的生物活性成分在抗癌治疗中的应用逐渐引起广泛关注。人参皂苷（ginsenosides）作为人参的重要活性成分，展现出显著的生物学效应，包括免疫调节、抗氧化及抗炎等功能。近年来的研究表明，人参不仅能够缓解放射治疗（放疗）引起的副作用，还可能增强放疗的疗效，显示出其作为辅助治疗药物的潜力。然而，尽管目前已有大量研究探讨人参在放疗中的应用，具体的作用机制仍需进一步澄清。此外，人参及其成分的临床应用价值也亟待更系统的研究与验证。文章旨在综述人参及其活性成分在人类肿瘤放疗中应用的研究进展，分析其在放疗中的作用机制，以期为相关领域的研究提供参考与启示。
Abstract：Panax ginseng, a traditional Chinese herbal medicine, has gradually attracted widespread attention for its potential application in cancer treatment due to its rich bioactive components. Ginsenosides, as the primary active constituents of ginseng, exhibit significant biological effects, including immunomodulation, antioxidant, and anti-inflammatory functions. Recent studies suggest that ginseng not only can alleviate the side effects induced by radiotherapy but may also enhance its therapeutic efficacy, demonstrating its potential as an adjuvant therapy. However, although numerous studies have explored the application of ginseng in radiotherapy, the specific mechanisms of action still require further clarification. Moreover, the clinical application value of ginseng and its components urgently needs more systematic investigation and validation. This article aims to review the research progress on the application of Panax ginseng and its active components in human tumor radiotherapy, analyzing their mechanisms of action in radiotherapy, to provide reference and insights for research in related fields.
[1]TAURO S, DHOKCHAWLE B, MOHITE P, et al. Natural anticancer agents:their therapeutic potential, challenges, and promising outcomes[J]. Current Medicinal Chemistry, 2024, 31(7):848-870.
[2]CHO H T, KIM J H, HEO W, et al. Explosively puffed ginseng ameliorates ionizing radiation-induced injury of colon by decreasing oxidative stress-related apoptotic cell execution in mice[J]. Journal of Medicinal Food, 2019, 22(5):490-498.
[3]ABDULRIDHA M K, AL-MARZOQI A H, AL-AWSI G R L, et al. Anticancer effects of herbal medicine compounds and novel formulations:a literature review[J]. Gastrointest Cancer, 2020, 51(3):765-773.
[4]BAUER-BUNTZEL C, BUNTZEL J, ZOMORODBAKHSCH B, et al. Phytotherapy in uro-oncology[J]. Urologie,2023, 62(1):3-10.
[5]孙金梦,张颖,郑泽君,等.基于网络药理学和分子对接技术探讨人参对牙周炎的潜在治疗机制[J].华西口腔医学杂志, 2024, 42(2):181-191.
[6]YANG Y, NAN Y, DU Y, et al. Ginsenosides in cancer:proliferation, metastasis, and drug resistance[J]. Biomed Pharmacother, 2024, 177:117049.
[7]LIU H, XIE T, LIU Y. Ginsenoside Rg3 inhibits the malignant progression of cervical cancer cell by regulating AKT2expression[J]. Heliyon, 2023, 9(8):e19045.
[8]OZDEMIR A, TUMKAYA L, MERCANTEPE T, et al. The protective effects of ginseng on x-irradiation-induced intestinal damage in rats[J]. Radiat Environ Biophys, 2023, 62(3):395-402.
[9]LI J W, WANG L, YU X D, et al. Panaxadiol targeting IL2 inducible T cell kinase promotes T cell immunity in radiotherapy[J]. Anticancer Drugs, 2023, 34(6):705-714.
[10]SONG S, PARK D, SEO S, et al. Effects of harvest time on phytochemical constituents and biological activities of Panax ginseng berry extracts[J]. Molecules, 2019, 24(18):3343.
[11]ZHAO Q, BAI L, ZHU D W, et al. Clinical efficacy and potential mechanism of ginseng polysaccharides in the treatment of non-small cell lung cancer based on meta-analysis associated with network pharmacology[J]. Heliyon, 2024, 10(6):e27152.
[12]HE M J, WANG N, ZHENG W X, et al. Ameliorative effects of ginsenosides on myelosuppression induced by chemotherapy or radiotherapy[J]. J Ethnopharmacol, 2021, 268:113581.
[13]LIU H, WANG Z Y, ZHOU Y C, et al. Immunomodulation of Chinese herbal medicines on NK cell populations for cancer therapy:a systematic review[J]. J Ethnopharmacol, 2021, 268:113561.
[14]YANG J, YU Z Y, LI S Y, et al. Identification of active ingredients in ginseng volatile oil:a strategy combining computer virtual screening with experimental validation[J]. Phytochem Anal, 2025, 36(3):640-656.
[15]LI X, CHU S F, LIN M Y, et al. Anticancer property of ginsenoside Rh2 from ginseng[J]. European Journal of Medicinal Chemistry, 2020, 203:112627.
[16]CHANGIZI V, GHAREKHANI V, MOTAVASELI E. Co-treatment with Ginsenoside 20(S)-Rg3 and curcumin increases radiosensitivity of MDA-MB-231 cancer cell line[J]. Iranian Journal Medical Science, 2021, 46(4):291-297.
[17]YANG L, CHEN J J, SHENG-XIAN T B, et al. Research progress on the antitumor molecular mechanism of ginsenoside Rh2[J]. The American Journal of Chinese Medicine, 2024, 52(1):217-230.
[18]ZHONG J, HE G T, MA X, et al. Triterpene-based prodrug for self-boosted drug release and targeted oral squamous cell carcinoma chemotherapy[J]. ACS Applied Materials Interfaces, 2024, 16(32):41960-41972.
[19]HAN X, WEI Q, LV Y, et al. Ginseng-derived nanoparticles potentiate immune checkpoint antibody efficacy by reprogramming the cold tumor microenvironment[J]. Molecular Therapy:the journal of the American Society of Gene Therapy, 2022, 30(1):327-340.
[20]KIM J, YOO J, KIM J S, et al. Anticancer effect of mountain ginseng on human breast cancer:comparison with farmcultivated ginseng[J]. Evidence-Based Complementary and Alternative Medicine, 2020, 2020:2584783.
[21]HAM S W, KIM J, JEON H, et al. Korean Red ginseng extract inhibits glioblastoma propagation by blocking the Wnt signaling pathway[J]. J Ethnopharmacol, 2019, 236:393-400.
[22]CHEN W J, YAO P F, VONG C T, et al. Ginseng:a bibliometric analysis of 40-year journey of global clinical trials[J].Journal Advanced Research, 2021, 34:187-197.
[23]BING S J, KIM M J, AHN G, et al. Acidic polysaccharide of Panax ginseng regulates the mitochondria/caspasedependent apoptotic pathway in radiation-induced damage to the jejunum in mice[J]. Acta Histochem, 2014, 116(3):514-521.
[24]FAN S S, ZHANG Z P, SU H, et al. Panax ginseng clinical trials:current status and future perspectives[J]. Biomed Pharmacother, 2020, 132:110832.
[25]YANG F X, LI J J, LAN Y P, et al. Potential application of ginseng in sepsis:applications of ginseng in sepsis[J]. J Ginseng Res, 2023, 47(3):353-358.
基本信息:
DOI：10.16068/j.1000-1824.2026.02.003
中图分类号:R273
引用信息:
[1]张凤仙,张松男,朴正日,等.人参及其活性成分在肿瘤放射治疗中的应用进展[J].延边大学医学学报,2026,49(02):7-11.DOI:10.16068/j.1000-1824.2026.02.003.
2025-10-09
2025
2025-11-03
2025
1
2026-02-28
2026-02-28