延边大学医学学报

目的：探讨重复经颅磁刺激（rTMS）联合齐拉西酮治疗精神分裂症（SCH）的临床效果。方法：选取2021年7月至2023年7月长治医学院附属和平医院收治的60例SCH患者作为研究对象，按掷骰子法将其分为对照组（30例，进行rTMS治疗）和观察组（30例，进行rTMS联合齐拉西酮治疗）。观察两组患者治疗效果、认知功能及血清因子水平。结果：观察组患者治疗的总有效率、成套神经心理状态测量表（RBANS）评分、血清脑源性神经营养因子（BDNF）、神经生长因子（NGF）的水平高于对照组患者（P <0.05）。结论：rTMS联合齐拉西酮治疗SCH，可有效提高患者治疗效果，改善其认知功能，促进其神经营养素的生成。

Objective To investigate the clinical effect of repetitive transcranial magnetic stimulation(rTMS) combined with ziprasidone in the treatment of schizophrenia(SCH). Methods Sixty patients with SCH admitted to Heping Hospital affiliated to Changzhi Medical College from July 2021 to July 2023 were selected as the study objects. They were divided into control group(30 cases, treated with rTMS) and observation group(30 cases, treated with rTMS combined with ziprasidone) by dice. The therapeutic effect, cognitive function and serum factor levels of the two groups were observed. Results The total effective rate, repeatable battery for the assessment of neuropsychological status(RBANS) scores, serum brain-derived neurotrophic factor(BDNF) and nerve growth factor(NGF) levels of the observation group were higher than those of the control group(P<0.05). Conclusion rTMS combined with ziprasidone in the treatment of SCH can effectively improve the therapeutic effect of patients, improve their cognitive function, and promote the production of neurotrophins.